Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
Identifieur interne : 000089 ( Main/Exploration ); précédent : 000088; suivant : 000090Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
Auteurs : Shou-Di He ; Sheng-Guang Huang ; Hui-Jun Zhu ; Xiao-Guang Luo ; Kang-Han Liao ; Jie-Yao Zhang ; Ning Tan ; De-Yu LiSource :
- Pharmaceutical Biology [ 1388-0209 ] ; 2020.
Abstract
Url:
DOI: 10.1080/13880209.2020.1711783
PubMed: 31971852
PubMed Central: 7034059
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000791
- to stream Pmc, to step Curation: 000791
- to stream Pmc, to step Checkpoint: 000082
- to stream Ncbi, to step Merge: 000E64
- to stream Ncbi, to step Curation: 000E64
- to stream Ncbi, to step Checkpoint: 000E64
- to stream Main, to step Merge: 000089
- to stream Main, to step Curation: 000089
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes</title><author><name sortKey="He, Shou Di" sort="He, Shou Di" uniqKey="He S" first="Shou-Di" last="He">Shou-Di He</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Huang, Sheng Guang" sort="Huang, Sheng Guang" uniqKey="Huang S" first="Sheng-Guang" last="Huang">Sheng-Guang Huang</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Zhu, Hui Jun" sort="Zhu, Hui Jun" uniqKey="Zhu H" first="Hui-Jun" last="Zhu">Hui-Jun Zhu</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Luo, Xiao Guang" sort="Luo, Xiao Guang" uniqKey="Luo X" first="Xiao-Guang" last="Luo">Xiao-Guang Luo</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Liao, Kang Han" sort="Liao, Kang Han" uniqKey="Liao K" first="Kang-Han" last="Liao">Kang-Han Liao</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Jie Yao" sort="Zhang, Jie Yao" uniqKey="Zhang J" first="Jie-Yao" last="Zhang">Jie-Yao Zhang</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Tan, Ning" sort="Tan, Ning" uniqKey="Tan N" first="Ning" last="Tan">Ning Tan</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Li, De Yu" sort="Li, De Yu" uniqKey="Li D" first="De-Yu" last="Li">De-Yu Li</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31971852</idno><idno type="pmc">7034059</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034059</idno><idno type="RBID">PMC:7034059</idno><idno type="doi">10.1080/13880209.2020.1711783</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000791</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000791</idno><idno type="wicri:Area/Pmc/Curation">000791</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000791</idno><idno type="wicri:Area/Pmc/Checkpoint">000082</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000082</idno><idno type="wicri:Area/Ncbi/Merge">000E64</idno><idno type="wicri:Area/Ncbi/Curation">000E64</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E64</idno><idno type="wicri:doubleKey">1388-0209:2020:He S:oridonin:suppresses:autophagy</idno><idno type="wicri:Area/Main/Merge">000089</idno><idno type="wicri:Area/Main/Curation">000089</idno><idno type="wicri:Area/Main/Exploration">000089</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes</title><author><name sortKey="He, Shou Di" sort="He, Shou Di" uniqKey="He S" first="Shou-Di" last="He">Shou-Di He</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Huang, Sheng Guang" sort="Huang, Sheng Guang" uniqKey="Huang S" first="Sheng-Guang" last="Huang">Sheng-Guang Huang</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Zhu, Hui Jun" sort="Zhu, Hui Jun" uniqKey="Zhu H" first="Hui-Jun" last="Zhu">Hui-Jun Zhu</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Luo, Xiao Guang" sort="Luo, Xiao Guang" uniqKey="Luo X" first="Xiao-Guang" last="Luo">Xiao-Guang Luo</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Liao, Kang Han" sort="Liao, Kang Han" uniqKey="Liao K" first="Kang-Han" last="Liao">Kang-Han Liao</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Jie Yao" sort="Zhang, Jie Yao" uniqKey="Zhang J" first="Jie-Yao" last="Zhang">Jie-Yao Zhang</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Tan, Ning" sort="Tan, Ning" uniqKey="Tan N" first="Ning" last="Tan">Ning Tan</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Li, De Yu" sort="Li, De Yu" uniqKey="Li D" first="De-Yu" last="Li">De-Yu Li</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Pharmaceutical Biology</title><idno type="ISSN">1388-0209</idno><idno type="eISSN">1744-5116</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p><bold>Context:</bold> Oridonin exhibits various pharmacological and physiological activities, including antioxidant, antibacterial, anti-inflammatory, pro-apoptotic, anticancer and neurological effects. However, its role in rheumatoid arthritis (RA) is yet to be revealed.</p><p><bold>Objective:</bold> We evaluated the effects of oridonin on the survival and autophagy of RA-fibroblast-like synoviocytes (FLSs).</p><p><bold>Materials and methods:</bold> RA-FLSs were treated with oridonin at serial concentrations of 0, 2, 4, 6, 8 and 10 µg/mL for 24, 48 and 72 h. Then, cell proliferation and apoptosis were measured. A GFP-LC3 plasmid was transfected into the cells to determine autophagy.</p><p><bold>Results:</bold> Oridonin suppressed RA-FLS proliferation in a dose-dependent manner. The half maximal inhibitory concentrations (IC<sub>50</sub>) of oridonin at 24, 48 and 72 h were 8.28, 7.88 and 8.35 µg/mL, respectively. Treatment with oridonin for 24 h increased apoptosis by 4.1%, and increased the protein levels of Bax and cleaved caspase-3 but significantly decreased the levels of IL-1β in the culture supernatant (<italic>p</italic> < 0.05). In addition, 6 h of oridonin treatment significantly decreased the number of GFP-LC3 punctate dots and inhibited the protein levels of ATG5 and Beclin1 by 80.01% and 42.12%, respectively. Chloroquine (CQ) significantly reinforced the effects of oridonin on inhibition of autophagy, suppression of proliferation, and induction of apoptosis in RA-FLSs (<italic>p</italic> < 0.05).</p><p><bold>Conclusions:</bold> Our results indicate that treatment with oridonin in combination with CQ inhibits autophagy and cell proliferation and induces apoptosis in RA-FLSs more effectively than treatment oridonin alone. This finding indicates that oridonin is a potential therapeutic agent for RA.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alsaleh, G" uniqKey="Alsaleh G">G Alsaleh</name></author><author><name sortKey="Nehmar, R" uniqKey="Nehmar R">R Nehmar</name></author><author><name sortKey="Bluml, S" uniqKey="Bluml S">S Bluml</name></author><author><name sortKey="Schleiss, C" uniqKey="Schleiss C">C Schleiss</name></author><author><name sortKey="Ostermann, E" uniqKey="Ostermann E">E Ostermann</name></author><author><name sortKey="Dillenseger, Jp" uniqKey="Dillenseger J">JP Dillenseger</name></author><author><name sortKey="Sayeh, A" uniqKey="Sayeh A">A Sayeh</name></author><author><name sortKey="Choquet, P" uniqKey="Choquet P">P Choquet</name></author><author><name sortKey="Dembele, D" uniqKey="Dembele D">D Dembele</name></author><author><name sortKey="Francois, A" uniqKey="Francois A">A Francois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartok, B" uniqKey="Bartok B">B Bartok</name></author><author><name sortKey="Firestein, Gs" uniqKey="Firestein G">GS Firestein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Booth, La" uniqKey="Booth L">LA Booth</name></author><author><name sortKey="Tavallai, S" uniqKey="Tavallai S">S Tavallai</name></author><author><name sortKey="Hamed, Ha" uniqKey="Hamed H">HA Hamed</name></author><author><name sortKey="Cruickshanks, N" uniqKey="Cruickshanks N">N Cruickshanks</name></author><author><name sortKey="Dent, P" uniqKey="Dent P">P Dent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, Y" uniqKey="Dai Y">Y Dai</name></author><author><name sortKey="Hu, S" uniqKey="Hu S">S Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deretic, V" uniqKey="Deretic V">V Deretic</name></author><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dokladny, K" uniqKey="Dokladny K">K Dokladny</name></author><author><name sortKey="Zuhl, Mn" uniqKey="Zuhl M">MN Zuhl</name></author><author><name sortKey="Mandell, M" uniqKey="Mandell M">M Mandell</name></author><author><name sortKey="Bhattacharya, D" uniqKey="Bhattacharya D">D Bhattacharya</name></author><author><name sortKey="Schneider, S" uniqKey="Schneider S">S Schneider</name></author><author><name sortKey="Deretic, V" uniqKey="Deretic V">V Deretic</name></author><author><name sortKey="Moseley, Pl" uniqKey="Moseley P">PL Moseley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elmore, S" uniqKey="Elmore S">S Elmore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Li, Xy" uniqKey="Li X">XY Li</name></author><author><name sortKey="Wu, Zb" uniqKey="Wu Z">ZB Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Firestein, Gs" uniqKey="Firestein G">GS Firestein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia, S" uniqKey="Garcia S">S Garcia</name></author><author><name sortKey="Liz, M" uniqKey="Liz M">M Liz</name></author><author><name sortKey="Gomez Reino, Jj" uniqKey="Gomez Reino J">JJ Gomez-Reino</name></author><author><name sortKey="Conde, C" uniqKey="Conde C">C Conde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibofsky, A" uniqKey="Gibofsky A">A Gibofsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, H" uniqKey="He H">H He</name></author><author><name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name></author><author><name sortKey="Wang, A" uniqKey="Wang A">A Wang</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Liang, G" uniqKey="Liang G">G Liang</name></author><author><name sortKey="Deng, X" uniqKey="Deng X">X Deng</name></author><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hua, Y" uniqKey="Hua Y">Y Hua</name></author><author><name sortKey="Shen, M" uniqKey="Shen M">M Shen</name></author><author><name sortKey="Mcdonald, C" uniqKey="Mcdonald C">C McDonald</name></author><author><name sortKey="Yao, Q" uniqKey="Yao Q">Q Yao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Humby, F" uniqKey="Humby F">F Humby</name></author><author><name sortKey="Manzo, A" uniqKey="Manzo A">A Manzo</name></author><author><name sortKey="Kirkham, B" uniqKey="Kirkham B">B Kirkham</name></author><author><name sortKey="Pitzalis, C" uniqKey="Pitzalis C">C Pitzalis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurley, Jh" uniqKey="Hurley J">JH Hurley</name></author><author><name sortKey="Young, Ln" uniqKey="Young L">LN Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikezoe, T" uniqKey="Ikezoe T">T Ikezoe</name></author><author><name sortKey="Chen, Ss" uniqKey="Chen S">SS Chen</name></author><author><name sortKey="Tong, Xj" uniqKey="Tong X">XJ Tong</name></author><author><name sortKey="Heber, D" uniqKey="Heber D">D Heber</name></author><author><name sortKey="Taguchi, H" uniqKey="Taguchi H">H Taguchi</name></author><author><name sortKey="Koeffler, Hp" uniqKey="Koeffler H">HP Koeffler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y Jiao</name></author><author><name sortKey="Ding, H" uniqKey="Ding H">H Ding</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S Huang</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name></author><author><name sortKey="Wei, W" uniqKey="Wei W">W Wei</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author><author><name sortKey="Zheng, F" uniqKey="Zheng F">F Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kato, M" uniqKey="Kato M">M Kato</name></author><author><name sortKey="Ospelt, C" uniqKey="Ospelt C">C Ospelt</name></author><author><name sortKey="Gay, Re" uniqKey="Gay R">RE Gay</name></author><author><name sortKey="Gay, S" uniqKey="Gay S">S Gay</name></author><author><name sortKey="Klein, K" uniqKey="Klein K">K Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ek" uniqKey="Kim E">EK Kim</name></author><author><name sortKey="Kwon, Je" uniqKey="Kwon J">JE Kwon</name></author><author><name sortKey="Lee, Sy" uniqKey="Lee S">SY Lee</name></author><author><name sortKey="Lee, Ej" uniqKey="Lee E">EJ Lee</name></author><author><name sortKey="Kim, Ds" uniqKey="Kim D">DS Kim</name></author><author><name sortKey="Moon, Sj" uniqKey="Moon S">SJ Moon</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Kwok, Sk" uniqKey="Kwok S">SK Kwok</name></author><author><name sortKey="Park, Sh" uniqKey="Park S">SH Park</name></author><author><name sortKey="Cho, Ml" uniqKey="Cho M">ML Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurowska, M" uniqKey="Kurowska M">M Kurowska</name></author><author><name sortKey="Rudnicka, W" uniqKey="Rudnicka W">W Rudnicka</name></author><author><name sortKey="Kontny, E" uniqKey="Kontny E">E Kontny</name></author><author><name sortKey="Janicka, I" uniqKey="Janicka I">I Janicka</name></author><author><name sortKey="Chorazy, M" uniqKey="Chorazy M">M Chorazy</name></author><author><name sortKey="Kowalczewski, J" uniqKey="Kowalczewski J">J Kowalczewski</name></author><author><name sortKey="Zi Kowska, M" uniqKey="Zi Kowska M">M Ziółkowska</name></author><author><name sortKey="Ferrari Lacraz, S" uniqKey="Ferrari Lacraz S">S Ferrari-Lacraz</name></author><author><name sortKey="Strom, Tb" uniqKey="Strom T">TB Strom</name></author><author><name sortKey="Ma Li Ski, W" uniqKey="Ma Li Ski W">W Maśliński</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lefevre, S" uniqKey="Lefevre S">S Lefevre</name></author><author><name sortKey="Knedla, A" uniqKey="Knedla A">A Knedla</name></author><author><name sortKey="Tennie, C" uniqKey="Tennie C">C Tennie</name></author><author><name sortKey="Kampmann, A" uniqKey="Kampmann A">A Kampmann</name></author><author><name sortKey="Wunrau, C" uniqKey="Wunrau C">C Wunrau</name></author><author><name sortKey="Dinser, R" uniqKey="Dinser R">R Dinser</name></author><author><name sortKey="Korb, A" uniqKey="Korb A">A Korb</name></author><author><name sortKey="Schnaker, Em" uniqKey="Schnaker E">EM Schnaker</name></author><author><name sortKey="Tarner, Ih" uniqKey="Tarner I">IH Tarner</name></author><author><name sortKey="Robbins, Pd" uniqKey="Robbins P">PD Robbins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Cy" uniqKey="Li C">CY Li</name></author><author><name sortKey="Wang, Eq" uniqKey="Wang E">EQ Wang</name></author><author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y Cheng</name></author><author><name sortKey="Bao, Jk" uniqKey="Bao J">JK Bao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marino, G" uniqKey="Marino G">G Marino</name></author><author><name sortKey="Niso Santano, M" uniqKey="Niso Santano M">M Niso-Santano</name></author><author><name sortKey="Baehrecke, Eh" uniqKey="Baehrecke E">EH Baehrecke</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcinnes, Ib" uniqKey="Mcinnes I">IB McInnes</name></author><author><name sortKey="Leung, Bp" uniqKey="Leung B">BP Leung</name></author><author><name sortKey="Liew, Fy" uniqKey="Liew F">FY Liew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mor, A" uniqKey="Mor A">A Mor</name></author><author><name sortKey="Abramson, Sb" uniqKey="Abramson S">SB Abramson</name></author><author><name sortKey="Pillinger, Mh" uniqKey="Pillinger M">MH Pillinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okamoto, H" uniqKey="Okamoto H">H Okamoto</name></author><author><name sortKey="Hoshi, D" uniqKey="Hoshi D">D Hoshi</name></author><author><name sortKey="Kiire, A" uniqKey="Kiire A">A Kiire</name></author><author><name sortKey="Yamanaka, H" uniqKey="Yamanaka H">H Yamanaka</name></author><author><name sortKey="Kamatani, N" uniqKey="Kamatani N">N Kamatani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parzych, Kr" uniqKey="Parzych K">KR Parzych</name></author><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockel, Js" uniqKey="Rockel J">JS Rockel</name></author><author><name sortKey="Kapoor, M" uniqKey="Kapoor M">M Kapoor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sacre, Sm" uniqKey="Sacre S">SM Sacre</name></author><author><name sortKey="Andreakos, E" uniqKey="Andreakos E">E Andreakos</name></author><author><name sortKey="Taylor, P" uniqKey="Taylor P">P Taylor</name></author><author><name sortKey="Feldmann, M" uniqKey="Feldmann M">M Feldmann</name></author><author><name sortKey="Foxwell, Bm" uniqKey="Foxwell B">BM Foxwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, Yj" uniqKey="Shin Y">YJ Shin</name></author><author><name sortKey="Han, Sh" uniqKey="Han S">SH Han</name></author><author><name sortKey="Kim, Ds" uniqKey="Kim D">DS Kim</name></author><author><name sortKey="Lee, Gh" uniqKey="Lee G">GH Lee</name></author><author><name sortKey="Yoo, Wh" uniqKey="Yoo W">WH Yoo</name></author><author><name sortKey="Kang, Ym" uniqKey="Kang Y">YM Kang</name></author><author><name sortKey="Choi, Jy" uniqKey="Choi J">JY Choi</name></author><author><name sortKey="Lee, Yc" uniqKey="Lee Y">YC Lee</name></author><author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name></author><author><name sortKey="Jeong, Sk" uniqKey="Jeong S">SK Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tlustochowicz, M" uniqKey="Tlustochowicz M">M Tlustochowicz</name></author><author><name sortKey="Sliwczynski, Am" uniqKey="Sliwczynski A">AM Sliwczynski</name></author><author><name sortKey="Brzozowska, M" uniqKey="Brzozowska M">M Brzozowska</name></author><author><name sortKey="Teter, Z" uniqKey="Teter Z">Z Teter</name></author><author><name sortKey="Marczak, M" uniqKey="Marczak M">M Marczak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tu, J" uniqKey="Tu J">J Tu</name></author><author><name sortKey="Hong, W" uniqKey="Hong W">W Hong</name></author><author><name sortKey="Zhang, P" uniqKey="Zhang P">P Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Korner, H" uniqKey="Korner H">H Korner</name></author><author><name sortKey="Wei, W" uniqKey="Wei W">W Wei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, K" uniqKey="Xu K">K Xu</name></author><author><name sortKey="Xu, P" uniqKey="Xu P">P Xu</name></author><author><name sortKey="Yao, Jf" uniqKey="Yao J">JF Yao</name></author><author><name sortKey="Zhang, Yg" uniqKey="Zhang Y">YG Zhang</name></author><author><name sortKey="Hou, Wk" uniqKey="Hou W">WK Hou</name></author><author><name sortKey="Lu, Sm" uniqKey="Lu S">SM Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, R" uniqKey="Yang R">R Yang</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Hu, J" uniqKey="Hu J">J Hu</name></author><author><name sortKey="Wen, J" uniqKey="Wen J">J Wen</name></author><author><name sortKey="Xue, L" uniqKey="Xue L">L Xue</name></author><author><name sortKey="Tang, M" uniqKey="Tang M">M Tang</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Fu, J" uniqKey="Fu J">J Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, C" uniqKey="Yu C">C Yu</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Duan, X" uniqKey="Duan X">X Duan</name></author><author><name sortKey="Fang, Y" uniqKey="Fang Y">Y Fang</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Wu, R" uniqKey="Wu R">R Wu</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, L" uniqKey="Zhu L">L Zhu</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="He, Z" uniqKey="He Z">Z He</name></author><author><name sortKey="Qin, Y" uniqKey="Qin Y">Y Qin</name></author><author><name sortKey="Shen, Q" uniqKey="Shen Q">Q Shen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="He, Shou Di" sort="He, Shou Di" uniqKey="He S" first="Shou-Di" last="He">Shou-Di He</name><name sortKey="Huang, Sheng Guang" sort="Huang, Sheng Guang" uniqKey="Huang S" first="Sheng-Guang" last="Huang">Sheng-Guang Huang</name><name sortKey="Li, De Yu" sort="Li, De Yu" uniqKey="Li D" first="De-Yu" last="Li">De-Yu Li</name><name sortKey="Liao, Kang Han" sort="Liao, Kang Han" uniqKey="Liao K" first="Kang-Han" last="Liao">Kang-Han Liao</name><name sortKey="Luo, Xiao Guang" sort="Luo, Xiao Guang" uniqKey="Luo X" first="Xiao-Guang" last="Luo">Xiao-Guang Luo</name><name sortKey="Tan, Ning" sort="Tan, Ning" uniqKey="Tan N" first="Ning" last="Tan">Ning Tan</name><name sortKey="Zhang, Jie Yao" sort="Zhang, Jie Yao" uniqKey="Zhang J" first="Jie-Yao" last="Zhang">Jie-Yao Zhang</name><name sortKey="Zhu, Hui Jun" sort="Zhu, Hui Jun" uniqKey="Zhu H" first="Hui-Jun" last="Zhu">Hui-Jun Zhu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000089 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000089 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7034059
|texte= Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31971852" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |